1046 Salivary Peroxide Kinetics with 6% Hydrogen Peroxide Whitening Strips

D.A. MCMILLAN, C. MAHONY, L.B. PATEL, X. ZHOU, R.E. BAILEY, and G.L. WALDEN, The Procter & Gamble Company, Mason, OH, USA

Objective: Previous research has demonstrated generally low salivary exposure to peroxide following use of specific peroxide-containing vital bleaching systems. This clinical trial was conducted to evaluate the salivary kinetics of strip-based, 6% hydrogen peroxide gel used for vital bleaching.

Methods: A total of 12 subjects (mean age = 36 years) applied 6% hydrogen peroxide strips to the maxillary arch for 5, 10, 30 and 60 minutes. Strips were removed, and then, unstimulated salivary samples were recovered for analysis. All samples (including pretreatment) were analyzed immediately after collection using validated auto-titration methods. Peroxide concentrations below the level of detection were recorded as “0”.

Results: At baseline, the median peroxide concentration was 0. After strip use, median peroxide concentrations in saliva were 0.017, 0.004, and 0.006%, and 0.002%, at 5, 10, 30, and 60 minutes respectively. These low salivary peroxide levels during and after treatment are generally consistent with those previously reported for other strip and tray-based systems. Overall, median salivary HP concentrations were less than 0.02% at any time point measured, and the 5-minute maximum did not exceed 0.05% peroxide. Mean AUC through 30-minutes was 0.227 ± 0.089 peroxide.

Conclusion: This clinical research confirms minimal systemic exposure and rapid degradation of hydrogen peroxide following use of 6.0% hydrogen peroxide whitening strips.

Seq #113 - Whitening, Malodor, Fluoride, Chewing Gum 3:45 PM-5:00 PM, Thursday, 26 June 2003 Svenska Massan Exhibition Hall B