What Is Ozonated Glycerin? Uses, Benefits, and Clinical Applications
A shelf-stable, odorless ozone delivery system for skin, dental, nasal, and integrative use
OG-S™ by Ozone Therapies Group
The Future of Ozone is Here
ADVANCED OZONATED GLYCERIN FOR SKIN, ORAL, NASAL, AND CLINICAL USE
Explore the OG-S™ collection including OG Paste, Skin Gel, and Travel Nasal Spray.
OG-S™ products are designed to deliver stabilized ozone support in a clean, odorless, water-soluble format that integrates seamlessly into daily wellness routines, cosmetic applications, and practitioner protocols.
Unlike traditional ozonated oils, OG-S™ products are lightweight, non-greasy, shelf-stable, and easy to use across a wide range of applications.
Used by doctors, dentists, veterinarians, wellness professionals, and consumers worldwide.
WHAT IS OZONATED GLYCERIN?
Ozonated glycerin is a stabilized form of ozone infused into glycerin, designed to deliver active oxygen in a controlled, shelf-stable format. It is used for skin support, oral care, nasal applications, cosmetic wellness, and advanced practitioner-led protocols.
Unlike traditional ozonated oils, ozonated glycerin is water-soluble, odorless, non-greasy, and stable for long-term storage without refrigeration.
WHY OG-S™ IS DIFFERENT
OG-S™ products are formulated using advanced stabilized ozonated glycerin technology designed to provide controlled oxygen release without the heavy texture, instability, or strong odor associated with traditional ozonated oils.
Key Benefits
• Odorless and easy to use
• Water-soluble and non-oily
• Shelf-stable with no refrigeration required
• Gentle on skin and mucosal tissue
• Fast-absorbing and cosmetically elegant
• Compatible with skin, oral, nasal, and professional applications
This next-generation ozone delivery system allows practitioners and consumers to incorporate ozone support into everyday routines with greater comfort and versatility.
POPULAR APPLICATIONS
SKIN + COSMETIC SUPPORT
• Daily hydration and barrier support
• Sensitive or reactive skin support
• Cosmetic rejuvenation and skin wellness
• Face, neck, and body applications
• Post-procedure cosmetic support
ORAL + DENTAL SUPPORT
• Gum and tissue support
• Dental wellness routines
• Oral microbiome support
• Post-procedure applications
NASAL + AIRWAY SUPPORT
• Nasal hydration and support
• Travel-friendly daily use
• Airway wellness routines
• Mucosal support
PROFESSIONAL + INTEGRATIVE USE
• Wound and skin recovery support
• Practitioner-led protocols
• Localized applications
• Cosmetic and wellness integration
FIND THE RIGHT OG PRODUCT FOR YOUR NEEDS
OG-S™ Skin Gel
Best for daily skin support, hydration, barrier repair, sensitive skin, and cosmetic rejuvenation.
OG Paste
Best for targeted applications where prolonged contact and a thicker consistency are preferred.
OG-S™ Travel Nasal Spray
Best for nasal support, travel use, daily airway wellness, and on-the-go convenience.
Pure OG-S™
Professional concentrated base formula currently temporarily sold out due to high demand.
WHY CUSTOMERS LOVE OG-S™ SKIN GEL
OG-S™ Skin Gel combines stabilized ozonated glycerin with advanced cosmetic ingredients including ceramides, collagen, amino acids, hyaluronic acid, and mineral-rich Japanese onsen water.
Designed for both cosmetic and wellness-focused use, Skin Gel delivers lightweight hydration and barrier support without feeling heavy or greasy.
Popular Uses Include
• Dry or sensitive skin support
• Daily hydration and skin maintenance
• Post-procedure cosmetic care
• Barrier repair and skin recovery
• Face, neck, and body applications
• Fast-absorbing daily ozone skincare support
Suitable for daily use and compatible with sensitive skin types.
PURE OG PASTE
Pure OG Paste delivers the benefits of stabilized ozonated glycerin in a thicker, higher-viscosity format designed for prolonged contact and targeted applications.
Its unique texture allows for more localized use while maintaining the odorless, water-soluble advantages of OG-S™ technology.
Common Applications Include
• Targeted skin applications
• Dental and oral support
• Practitioner protocols
• Localized cosmetic use
• Areas requiring extended contact time
Trusted by integrative practitioners seeking a more concentrated application format.
OG-S™ TRAVEL NASAL SPRAY
Designed for convenient daily use, OG-S™ Travel Nasal Spray delivers stabilized ozonated glycerin in an easy-to-use portable format.
Popular for travel, seasonal wellness routines, and airway support, this shelf-stable spray provides a simple way to incorporate ozonated glycerin into everyday life.
Features
• Odorless and non-greasy
• Travel-friendly design
• Shelf-stable without refrigeration
• Gentle daily-use format
• Available in multiple strengths
TEMPORARILY SOLD OUT DUE TO HIGH DEMAND
Pure OG-S™ professional base formula is currently unavailable while inventory is replenished.
In the meantime, explore OG Paste, OG-S™ Skin Gel, and OG-S™ Travel Nasal Spray available now.
WHY PRACTITIONERS CHOOSE OG-S™
OG-S™ products are trusted by doctors, dentists, veterinarians, and integrative practitioners worldwide for cosmetic, wellness, and professional applications.
Applications Commonly Include
• Dermatology and skin barrier support
• Dental irrigation and post-procedure care
• Nasal and airway wellness routines
• Cosmetic recovery support
• Sensitive skin applications
• Integrative wellness protocols
REQUEST A WHOLESALE ACCOUNT
Healthcare professionals, clinics, dental offices, wellness practices, retailers, and distributors are invited to apply for wholesale pricing through Ozone Therapies Group.
Wholesale Ordering Options
Orders over $500 qualify for a 30% wholesale discount applied as a refund after your order is placed.
You may also request a custom invoice by emailing your product names and quantities directly to:
ozonetherapiesgroupinfo@gmail.com
Wholesale support is available for practitioners, offices, distributors, and qualified businesses interested in incorporating OG-S™ products into professional or retail settings.
OG product sales help fund educational events, clinical education access, and continued ozone product innovation through Ozone Therapies Group.
Stabilized Ozonated Glycerin Gel – Precision Formulated, Broadly Versatile
Pure OG-S is a next-generation ozonated glycerin gel, engineered through a patented stabilization process developed over 20 years in Japan. This water-soluble, syrup-like gel delivers the active power of ozone without odor, refrigeration, or degradation—designed for professionals and individuals seeking a clean, effective way to integrate ozone into protocols or daily routines.
Unlike traditional ozonated oils that break down quickly and carry a strong scent, Pure OG-S uses 100% natural-grade glycerin to safely and stably hold ozone in solution. It remains shelf-stable for up to 3 years at room temperature, with a smooth, non-irritating texture that’s suitable for even the most sensitive applications.
✦ Why Professionals and Consumers Choose It:
Advanced ozone delivery system—no mixing, no bubbling
Backed by 20 years of clinical R&D in Japan
Stable for 3 years with no refrigeration required
Clean, smooth application with a slightly sweet finish
Water-soluble and easy to incorporate into custom protocols
No preservatives, no scent, no artificial ingredients
Use: Apply as needed in your preferred modality or setting. Suitable for skin, mucosal, and other professional applications.
High-Adherence Ozone Delivery – Developed for Targeted, Lasting Application
Pure OG Paste is a high-viscosity, concentrated form of stabilized ozonated glycerin, created for long-lasting adherence and precise placement. Built on the same patented platform as Pure OG-S, this formula offers a thicker texture ideal for localized use, prolonged contact, or professional settings where ozone needs to stay active and stable.
Crafted in Japan and perfected over two decades, the paste is odorless, shelf-stable at room temperature, and contains no artificial ingredients. Its smooth, ointment-like consistency supports intensive hydration and acts as a functional base for a wide variety of applications.
✦ Why It’s Trusted by Clinics and Practitioners:
High-viscosity formula for targeted use and extended contact
Delivers active ozone without odor, irritation, or mess
No refrigeration needed—stays potent for 3 years
Ideal for slow-release ozone exposure or overnight use
No preservatives, synthetics, or added fragrance
Made with 100% natural-grade glycerin
Use: Apply a small amount where deeper support or stronger adhesion is needed. Integrates easily into personal or professional care protocols.
All-in-One Hydration Gel Infused with Stabilized Ozone Technology
OG-S Skin Gel delivers full-spectrum skin support in one simple step. Formulated in Japan using a patented method of ozone stabilization, this lightweight gel combines stabilized ozonated glycerin with skin-repairing ingredients including ceramides, amino acids, collagen, hyaluronic acid, and Tamatsukuri Onsen Water.
Created for both professionals and personal users, this gel absorbs quickly, leaves no residue, and is clinically tested for sensitive and reactive skin. It’s ideal for anyone seeking barrier repair, hydration, and antioxidant support—without layering multiple products.
✦ Key Features:
Combines toner, serum, and moisturizer into one
No ozone odor, no refrigeration required
Rich in bioactive peptides, natural lipids, and HA complexes
Designed for all skin types, including hypersensitive and pediatric
Absorbs fast with a silky, lightweight finish
Ideal for simplifying ozone skincare in clinical or home settings
Use: Apply 1–2 pumps after cleansing. Use day or night for deeply replenished, balanced skin.
OG-S™ Travel is your daily nasal defense—powered by 5% ozonated glycerin and sterile saline, stabilized through our proprietary Stable OG™ Technology. Unlike other formulas that degrade or require refrigeration, OG-S™ stays potent, shelf-stable, and ready when you are.
Whether you’re hopping on a flight, commuting through city smog, or just want clean, hydrated nasal passages—this is your carry-on essential.
✓ Supports immune and respiratory wellness
✓ Soothes, hydrates, and protects nasal passages
✓ No ozone odor, no preservatives
✓ Shelf-stable—no refrigeration required
✓ TSA-approved amber glass travel bottle
This isn’t just ozone. This is OG-S™.
Key Features:
• 5% OG-S™ (ozonated glycerin) + sterile saline
• Powered by Stable OG™ Technology
• Designed for consistent daily use
• Trusted by integrative health professionals
• Exclusive to Ozone Therapies Group
Ingredients:
Sterile Saline (Water, Sodium Chloride), OG-S™ Ozonated Glycerin (5%)
Suggested Use:
Shake gently. Spray twice per nostril daily or as needed. For nasal use only. Do not ingest.
Storage:
Shelf-stable. Store at room temperature. No refrigeration needed.
OG product sales fund our educational events, research access, and allow practitioners and patients to experience OG firsthand.
Why Practitioners Choose OG-S™
OG-S is trusted by doctors, dentists, and veterinarians around the world. It integrates seamlessly into ozone protocols, cosmetic procedures, and wound care—all without the mess or smell of traditional oils.
Applications: Dermatology & Barrier Repair | Dental irrigation and post-extraction care | ENT/Nasal protocols + nebulization | Injection site recovery | Pediatric and geriatric skin issues
What Makes OG-S™ Different?
Mediplus Pharma developed a unique molecule—Trioxepane—that forms when glycerin is ozonated using a proprietary method. It slowly releases oxygen atoms in a controlled, bioactive way.
This is the core innovation behind every OG-S product.
Mechanisms Confirmed:
- Activates Nrf2 pathway (reduces inflammation, supports healing)
- Promotes collagen, hyaluronic acid, and ceramide synthesis
- ESR-confirmed OG radicals with antioxidant effects
Academic + Clinical Partners:
- Showa Medical University
- University of Ferrara
- University of North Carolina
- Tokyo University of Science
Real Results from Clinical Practice
Used in over 650 cases by Dr. Jim Bridge, DVM—including canine cancer, joint degeneration, and oral disease.
Top Clinical Benefits:
- Rapid pain relief and inflammation reduction
- Tumor regression with localized injection (“circle the dragon” technique)
- Faster post-op recovery and tissue repair in both humans and animals
- Full reversal of sinusitis, fungal liver infections, and skin lesions
“We’ve seen tumors shrink, ulcers close, and patients—animal and human—recover faster and more comfortably.” — Jim Bridge, DVM
Safety Precautions
Courtesy of Dr. Jim Bridge
OG is highly concentrated, with a very low pH (~2) and hypertonic properties. Dilution and buffering are essential to ensure safety in clinical use.
To minimize adverse side effects, buffer OG with sodium bicarbonate to bring the pH closer to neutral before administration.
Important clinical guidance based on observed use:
Recommended dilution for IV use: 2.5% OG in sterile water
Maximum dose: 1 mL of OG per 6 pounds (3 kg) of body weight
Gradual dosing protocol is strongly advised:
Start with ¼ of calculated dose for first injection (IV or IP)
Use ½ dose for the second
¾ dose for the third
Full dose for all subsequent administrations
Possible side effects (observed at 5% concentration):
Transient hematuria (pink urine) for a few hours post-IV (similar to 10-pass or EBOO)
GI cramping or osmotic laxative effect if the dose is too high (IV or oral)
Special note for oncology cases:
Start with extremely low doses and increase only as tolerated. Rapid cancer cell die-off can cause serious complications if the dose is too aggressive early on.
Always adjust treatment based on patient tolerance and response.
Frontiers9 Ozone Conference + OG Summit
November 6–8, 2025
OG Summit (Thursday): Hands-on OG workshops, protocols, live demos
General Conference (Fri/Sat): CE/CME credits, legal/FDA updates, anti-aging, cancer therapies
Includes:
- 21 CE/CME units
- Cocktail reception, awards dinner
- Product samples + swag bag
Hotel Rate: $259–339/night (resort fee + parking included)